Inhibitory Effect of Bunium persicum Boiss Essential Oil on Castor-OilInduced Diarrhea
Authors
Abstract:
Background & Aims: Bunium persicum Boiss. Belongs to Apiaceae family and its fruit contains high level of essential oils used as native medicinal plant in traditional medicine. Methods: The essential oil of Bunium persicum (EOBP) was extracted by Clevenger apparatus using hydrodistillation. Lethal dose, 50% (LD50) was calculated based on Lorke’s method. Effects of EOBP (20- 80 mg/kg) on upper gastrointestinal transit and on castor oil-induced diarrhea were investigated in adult Wistar rats weighting 200-220 g of eithersex. Results: The LD50 was determined as 375 mg/kg. Abnormal behavioural activities included lethargy, weakness, recumbence, and slow and shallow respiration. EOBP (20 mg/kg)showed inhibitory effects more than atropine where high doses (40 mg/kg) had same inhibition in contrast with atropine. EOBP inhibited intestinal motility more than atropine at lower doses. EOBP inhibitory effect was enhanced with atropine insignificantly. The EOBP (20 and 80 mg/kg) also caused a dose-dependent decrease of diarrheal parameters and markedly protected rats against castor oil-induced diarrhea. The maximal effect of the EOBP wassimilar to loperamide, one of the most efficacious and widely employed antidiarrheal drugs at the present time. Conclusion: These primary data indicated that the plant may contain some biologically active constituents that may reveal antimotility and antidiarrheal effects and support the popular therapeutic use of Bunium persicum in traditional medicine for gastrointestinal disorders
similar resources
Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model
BACKGROUND We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis. METHODS To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days. After 24 h mice were infected intraperitonealy with 1×10(4) tachyzoites of T. gondii, RH strain. In order to investig...
full textEffects of Bunium persicum (Boiss.) Essential Oil on the Contractile Responses of Smooth Muscle (An in vitro Study)
Bunium persicum (Boiss.) is an economically important medicinal plant growing wild in arid regions in Iran. The essential oil of B. persicum (EOBP) was extracted using hydrodistillation. A total of eighteen compounds, representing 96.14 % of the oil was identified by gas chromatography/mass spectrometry (GC/MS).The main compounds were cuminaldehyde (23.04 %), gamma-terpinene (14.48 %), trans-3-...
full textSynergistic Effect of Zataria multiflora Boiss. and Bunium persicum (Boiss.) B. Fedtsch. Essential Oils on Linseed Oil Oxidative Stability
We studied the antioxidant activities of the essential oils of Zataria multiflora Boiss. (ZEO) and Bunium persicum (Boiss.) B. Fedtsch (BEO) in mixed form on linseed oil using (DPPH•), (ABTS•+), H2O2 scavenging, and reducing power assays. After calculation of IC50 for ZEO and BEO separately, interactions of the essential oils were investigated at the form of mixture and the results were given...
full textAntifungal effect of essential oil of Bunium persicum on Candida albicans, In vitro study
Introduction: Bunium persicum is a gramine plant from Umbelliferae family. Candida albicans is a kind of yeast known as normal flora of skin and gastrointestinal tract (GIT), respiratory and genitourinary (GU) mucosa. This fungi makes disease in immunodeficient individuals. The aim of this study was to assess the antifungal effect of essential oil of Bunium persicum on Candida albicans. Methods...
full textEffects of Bunium persicum (Boiss.) Essential Oil on the Contractile Responses of Smooth Muscle (An in vitro Study)
Bunium persicum (Boiss.) is an economically important medicinal plant growing wild in arid regions in Iran. The essential oil of B. persicum (EOBP) was extracted using hydrodistillation. A total of eighteen compounds, representing 96.14 % of the oil was identified by gas chromatography/mass spectrometry (GC/MS).The main compounds were cuminaldehyde (23.04 %), gamma-terpinene (14.48 %), trans-3...
full textsynergistic effect of zataria multiflora boiss. and bunium persicum (boiss.) b. fedtsch. essential oils on linseed oil oxidative stability
we studied the antioxidant activities of the essential oils of zataria multiflora boiss. (zeo) and bunium persicum (boiss.) b. fedtsch (beo) in mixed form on linseed oil using (dpph•), (abts•+), h2o2 scavenging, and reducing power assays. after calculation of ic50 for zeo and beo separately, interactions of the essential oils were investigated at the form of mixture and the results were given...
full textMy Resources
Journal title
volume 21 issue 2
pages 139- 150
publication date 2014-03-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023